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With this intention, he purchased the lease of a house in Great Marlborough Street; and in the summer of 1801, built a lecture room. He brought his family to town, and once more looked forward with hope. The flattering success he soon met with, and a short residence at Harrowgate in the autumn, contributed to afford a temporary renovation of health and spirits; it was, however, but a short and delusive gleam of prosperity which now dawned upon him; for, confiding too much in his newly increased strength, he exerted himself to a much greater degree than prudence would have suggested. In the course of the following winter, he delivered not less than eight courses of lectures, two on chemistry, two on experimental philosophy, a private course on the same subject, one on mineralogy, and the course to which this sketch is prefixed, which he also delivered in an apartment at Tom's Coffee house, for the convenience of medical students, and others, in the city. Besides these, he commenced two courses on botany, one at Brompton, and the other at his own house; but a return of ill health prevented his concluding them. It was not to be expected, that a constitution so impaired and debilitated, could long support this continued labour of composition and recitation; accordingly he became affected with a consequent disorder, which rapidly exhausted his strength; and, being unable to employ the only probable means of recovering it, he became more incapable of exertion. His spirits however were roused, and he ceased not to use every means of increasing his practice. In the spring of 1802, the office of physician to the St. Mary le Bonne Dispensary happened to be vacant, and he became a candidate; he was more than commonly anxious to obtain this situation. It seemed to him, as if his future good or ill fortune depended altogether upon the event of his canvass, he spared no effort to ensure his success; and accordingly was appointed to the situation in May. His life now drew near a close. Little was he calculated to bear the accumulated labours, and extreme fatigue, to which he was daily exposed. Any benefit which might have resulted from constant and well regulated occupation was frustrated; for whilst he still suffered from the vividness of his conception, representing to him in mournful colours the occurrences of his past life, he became liable to other evils, not less injurious and destructive. The practice of medicine requires both vigorous health of body and firmness of mind. Dr. Garnett, now greatly weakened in body, and not exempt from anxiety of mind, became more and more susceptible to the action of morbific matter. It was not long before he received the contagion of typhous fever, whilst attending a patient, belonging to that very dispensary of which he had been so anxious to become physician. He laboured under the disorder for two or three weeks, and died the 28th of June, 1802; and was buried in the new burial ground of the parish of St. James, Westminster.

Thus was lost to society a man, the ornament of his country, and the general friend of humanity. In his personal attachments, he was warm and zealous. In his religion he was sincere, yet liberal to the professors of contrary doctrines. In his political principles, he saw no end, but the general good of mankind; and, conscious of the infirmity of human judgment, he never failed to make allowances for error. As a philosopher, and a man of science, he was candid, ingenuous, and open to conviction; he never dealt in mystery, or pretended to any secret in art; he was always ready in explanation, and desirous of assisting every person willing to acquire knowledge. Virtue was the basis of all his actions; science never possessed a fairer fabric, nor did society ever sustain a greater loss.

LECTURE I. INTRODUCTION

I AM well aware of the difficulties attending the proper composition of a popular course of lectures on the animal economy, which must be essentially different from those generally delivered in the schools of medicine; because it professes to explain the structure and functions of the living body, to those who are supposed to be unacquainted with the usual preliminary and collateral branches of knowledge. It must be obvious to every one, that it can be by no means an easy task to give in a few lectures, a perspicuous view of so extensive a subject; but I trust that the consideration of this difficulty will readily extend to me your indulgence.

That such a course, if properly conducted, must be interesting, needs scarcely to be observed; for the more we examine the structure and functions of the human body, the more we admire the excellence of the workmanship, and beauty of contrivance, which presents itself in every part, and which continually shows the hand of omniscience. The most ingenious of human inventions, when compared with the animal frame, indicate a poverty of contrivance which cannot fail to humble the pretensions of the sons of men. Surely then there are few who will not feel a desire to become acquainted with subjects so interesting.

But there is another point of view which will place the utility of such inquiries in a still stronger light. We shall afterwards see, that our life is continually supported by the action of a number of substances, by which the body is surrounded, and which are taken into the stomach for its nourishment. On the due action of these depends the pleasant performance of the different functions, or the state of health; without which, riches, honours, and every other gratification, become joyless and insipid.

By understanding the manner in which these powers act, or, in other words, by becoming acquainted with the principles of physiology, we shall be enabled to regulate them, so as, in a great measure, to guard against the numerous ills that flesh is heir to: for it is universally agreed, that by far the greatest part of the diseases to which mankind are subject, have been brought on by intemperance, imprudence, and the neglect of precautions, which often arises from carelessness, but much oftener from ignorance of those precautions.

Physiological ignorance is, undoubtedly, the most abundant source of our sufferings; every person accustomed to the sick must have heard them deplore their ignorance of the necessary consequences of those practises, by which their health has been destroyed: and when men shall be deeply convinced, that the eternal laws of nature have connected pain and decrepitude with one mode of life, and health and vigour with another, they will avoid the former and adhere to the latter.

It is strange, however, to observe that the generality of mankind do not seem to bestow a single thought on the preservation of their health, till it is too late to reap any benefit from their conviction: so that we may say of health, as we do of time, we take no notice of it but by its loss; and feel the value of it when we can no longer think of it but with retrospect and regret.

When we take a view of the human frame, and see how admirably each part is contrived for the performance of its different functions, and even for repairing its own injuries, we might at first sight imagine, that such a structure, unless destroyed by external force, should continue for ever in vigour, and in health: and it is by mournful experience alone that we are convinced of the contrary. The strongest constitution, which never experienced the qualms of sickness, or the torture of disease, and which seems to bid defiance to the enemies of health that surround it, is not proof against the attacks of age. Even in the midst of life we are in death; how many of us have contemplated with admiration the graceful motion of the female form; the eye sparkling with intelligence; the countenance enlivened by wit, or animated by feeling: a single instant is sufficient to dispel the charm: often without apparent cause, sensation and motion cease at once; the body loses its warmth, the eyes their lustre, and the lips and cheeks become livid. These, as Cuvier observes, are but preludes to changes still more hideous. The colour passes successively to a blue, a green, and a black; the flesh absorbs moisture, and while one part of it escapes in pestilential exhalations, the remaining part falls down into a putrid liquid mass. In a short time no part of the body remains, but a few earthy and saline principles; its other elements being dispersed through air, or carried off by water, to form new combinations, and afford food for other animals.

The human body has been defined to be a machine composed of bones and muscles, with their proper appendages, for the purpose of motion, at the instance of its intelligent principle. From this principle, nerves, or instruments of sensation, are likewise detached to the various parts of the body, for such information as may be necessary to determine it to those motions of the body, which may conduce to the happiness of the former, and the preservation of both.

It may perhaps be objected to this definition, that the body consists of other parts besides bones, muscles, and nerves; this is undoubtedly true; but, if we examine more minutely, we shall find that all the other parts, as well as functions of the body, seem only to be subservient to the purposes I have mentioned. For, in the first place, the muscles which are necessary to the motions of the body, are, from the nature of their constitution, subject to continual waste; to repair which waste, some of the other functions have been contrived.

Secondly, most of the other parts and functions of the body, are either necessary to the action of the muscles, or to the operation of the intelligent principle, or both.

Lastly, from the sensibility, and delicate structure, of the muscles and nerves, they require to be defended from external injuries: this is done by membranes, and other contrivances, fitted for the purpose.

To see this more clearly, we shall examine a little more particularly how each of the functions is subservient to the muscular and nervous systems. For this purpose it may be observed, 1st. that the stomach and digestive faculties serve to assimilate the food, or convert it into matter proper to repair the continual waste of solids and fluids. The circulation of the blood besides being absolutely necessary, as we shall afterwards see, to the action of the muscles, distributes the nourishment, thus assimilated and prepared by the stomach, to all parts of the body. The different glands separate liquors from the blood, for useful, but still for subservient purposes. Thus the salivary glands, stomach, pancreas, and liver, separate juices necessary to the proper digestion and assimilation of the food. The kidneys serve to strain off from the blood the useless and superfluous water, salts, &c. which if allowed to remain in the body would be very injurious to it.

We shall afterwards see, that the nerves are not only instruments of sensation, but the origin of motion; it being immediately by their means that the muscles are moved. A certain degree of heat is necessary to keep the blood fluid, and also to the action of the nerves; without either of which, no motion could be performed. Respiration or breathing is so necessary to life, that it cannot exist, even a few minutes, without the exercise of that function; and yet we shall afterwards see, that the ultimate end of respiration is to keep the body in a proper state, for the purposes of muscular motion and sensation.

The skin serves like a sheath to defend the body from injuries; the skull serves the same purpose to the brain, which is the origin of the nerves. The different membranes separate the fibres, muscles, nerves, and various organs of the body, from each other. Hence we see that there is no impropriety, in calling the human body a machine composed of bones and muscles, with their proper appendages, for the purpose of motion, at the instance of its intelligent principle.

In order to show more clearly how each part is subservient to these ends, I shall give a short account of the structure of the human body, but I must premise, that the nature of this course will prevent my entering minutely into anatomical detail. All that can be done is, to give such a general outline of anatomy and physiology, as will furnish individuals with so much knowledge of themselves, as may enable them to guard against habitual sickness.

Among the solid parts of the human frame the bones stand conspicuous. Their use is, to give firmness and shape to the body. Some of them likewise serve as armour, or defense, to guard important parts; thus the skull is admirably contrived to defend the brain; and the spine or backbone is designed, not only to strengthen the body, but to shield that continuation of the brain, called the spinal marrow, from whence originate great numbers of nerves, which pass through convenient openings of this bone, and are distributed to various parts of the body. In the structure of this, as well as every other part, the wisdom of the Creator is manifest. Had it been a single bone, the loins must have been inflexible; to avoid which, it consists of a number of small bones, articulated or joined together with great exactness, which are strengthened by compact ligaments. Hence it becomes capable of various inflections, without injuring the nerves, or diminishing that strength which is so much required.

The whole system of bones, or skeleton, is constructed of several parts, of different shapes and sizes, joining with one another in various manners, and so knit together, as best to answer to the motions which the occasions of the animal may require.

These bones serve as levers for the muscles to act on; which last serve as mechanical powers, to give the machine various motions, at the command of the will.

The muscles are fleshy fibres, attached by their extremities to the bones. When the fibres shorten themselves, the two parts into which the muscle is inserted are brought nearer; and, by this simple contrivance, all the motions of animals are performed, and their bodies carried from one place to another.

Joints are provided with muscles for performing the motions for which they are adapted; every muscle pulling the bone, to which it is attached, in its own particular direction. Hence the muscles may be considered as so many moving forces, as was before hinted; and their strength, the distance of their insertion from the centre of motion, the length of the lever to which they are attached, and the weight connected with it, determine the duration and velocity of the motions which they produce. Upon these different circumstances depend the different kinds of motion performed by various animals, such as the force of their leap, the extent of their flight, the rapidity of their course, and their address in catching their prey.

Most of the muscles act upon the bones, so as to produce the effects of a lever of the third kind, as it is termed by mechanics, where the power acts between the centre of motion and the weight; hence it has a mechanical disadvantage; as an instance of this, the muscle which bends the forearm, is inserted about one eighth or one tenth of the distance from the centre of motion that the hand is, where the weight or resistance is applied; hence the muscle must exert a force eight or ten times greater than the weight to be raised. But this disadvantage is amply compensated by making the limbs move with greater velocity; besides, if room had been given for the muscles to act with greater advantage, the limbs must have been exceedingly deformed and unwieldy.¹

The muscles, in general, at least those which serve for voluntary motion, are balanced by antagonists, by means of which they are kept beyond their natural stretch. When one of two antagonists is contracted by the will, the other relaxes in order to give it play; or at least becomes overpowered by the contraction of the first. Also when one of such muscles happens to be paralytic, the other being no longer balanced, or kept on the stretch, immediately contracts to its natural length, and remains in that situation. The part to which it is fixed will, of course, be affected accordingly. If one of the muscles which move the mouth sideways be destroyed, the other immediately contracting, draws the mouth awry; and in that situation it remains. The same may be observed of the leg, the arm, and other parts. Some muscles assist one another in their action, while others have different actions; according to their shapes, the course of their fibres, and the structure of the parts they move.

According to the shape and nature of the bones to be moved, and of the motions to be performed, the muscles are either long, or short; slender, or bulky; straight, or round. Where a great motion is required, as in the leg, or arm, the muscles are long; where a small motion is necessary, they are short; for a strong motion they are thick, and for a weak one slender.

Some of the muscles are fastened to, and move bones; others cartilages, and others again other muscles, as may best suit the intention to be answered.

With respect to the bones, some are solid and flattened; others hollow and cylindrical. Every cylindrical bone is hollow, or has a cavity containing a great number of cells, filled with an oily marrow. Each of these cells is lined with a fine membrane, which forms the marrow. On this membrane, the blood vessels are spread, which enter the bones obliquely, and generally near their middle; from some branches of these vessels the marrow is secreted; while others enter the internal substance of the bones for their nourishment; and the reason why they enter the bones obliquely is, that they may not weaken them by dividing too many fibres in the same place.

The bones being made hollow, their strength is greatly increased without any addition to their weight; for if they had been formed of the same quantity of matter without any cavities, they would have been much weaker; their strength to resist breaking transversely being proportionate to their diameters, as is evident from mechanics.

All the bones, excepting so much of the teeth as are out of the sockets, and those parts of other bones which are covered with cartilages, are surrounded by a fine membrane, which on the skull is called pericranium, but in other parts periosteum. This membrane serves for the muscles to slide easily upon, and to hinder them from being lacerated by the hardness and roughness of the bones.

But though the apparatus which I have been describing is admirably contrived for the performance of motion; it would continue for ever inactive, if not animated by the nervous system.

The brain is the seat of the intelligent principle: from this organ, white, soft, and medullary threads, called nerves, are sent off to different parts of the body: some of them proceed immediately from the brain to their destined places, while the greater number, united together, perforate the skull, and enter the cavity of the backbone, forming what we call the spinal marrow, which may be regarded as a continuation of the brain. Portions of the spinal marrow pass through different apertures to all parts of the body.

We are not conscious of the impression of external objects on our body, unless there be a free communication of nerves, between the place where the impression is made and the brain. If a nerve be divided, or have a ligature put round it, sensation is intercepted.

There is perhaps only one sense which is common to all classes of animals, and which exists over every part of the surface of the body; I mean the sense of touch. The seat of this sense is in the extremities of the nerves distributed over the skin; and by means of it we ascertain the resistance of bodies, their figure, and their temperature.

The other senses have been thought to be only more refined modifications of the sense of touch; and the organs of each are placed near the brain on the external surface of the head. The sense of sight, for instance, is seated in the eye; the hearing in the ear; the smell in the internal membrane of the nose; and the taste in the tongue.

The light; the pulses, or vibrations of the air; the effluvia floating in the atmosphere; saline particles, or particles which are soluble in water or saliva, are the substances which act upon these four senses; and the organs which transmit their action to the nerves, are admirably adapted to the respective nature of each. The eye presents to the light a succession of transparent lenses to refract its rays; the ear opposes to the air membranes, fluids, and bones, well fitted to transmit its vibrations; the nostrils, while they afford a passage to the air in its way to the lungs, intercept any odorous particles which it contains, and the tongue is provided with spongy papillae to imbibe the sapid liquors which are the objects of taste.

It is by these organs that we become acquainted with what passes around us; by these we know that a material world exists. We may however observe, that the nervous system, besides making us acquainted with external things, gives us notice of many changes that take place within our own body. Internal pain warns us of the presence of disease; and the disagreeable sensations of hunger, thirst, and fatigue, are signs of the body standing in need of refreshment or repose.

Concerning the manner in which we become acquainted with external things, by means of the senses, we know nothing. Many hypotheses have been offered to explain this: none of them however are the result of experiment and observation. Many philosophers have supposed the universe to be filled with an extremely subtile fluid, which they have termed ethereal; and this hypothesis has been sanctioned by the illustrious authority of Newton. He however merely offered it in the modest form of a query, for the attention of other philosophers; little thinking that it would be made use of to explain phenomena which they did not understand. His query about a subtile elastic fluid pervading the universe, and giving motion and activity to inert masses of matter, and thereby causing the phenomena of attraction, gravitation, and many other appearances in nature, was immediately laid hold of by his followers, as a fact sufficiently supported, because it seemed to have the sanction of so great an authority.

This hypothesis was made use of to explain a great number of phenomena, and the physiologists, whose theories were generally influenced by the prevailing philosophy, eagerly laid hold of it to explain the phenomena of sensation, and muscular motion. When an impression was made upon any part of the external surface of the body, whether it was occasioned by heat, or mechanical impulse, they supposed, that the ether in the extremities of the nerves was set in motion. This motion, from the energy of the ether, is communicated along the nerves to the brain, and there produces such a change as occasions a consciousness of the original impression, and a reference in the mind to the place where it was made. Next they supposed, that the action of the will caused a motion of the ether to be instantly propagated along the nerves that terminate in the fibres of the muscles, which stimulated them to contraction.

Other philosophers imagined, that a tremulous motion was excited in the nerves themselves, by the action of external impulses, like the motions excited in the string of a harp. These motions they supposed to be propagated along the nerves of sense, to the brain, and from thence along the motory nerves, to the muscles.

Before they attempted this explanation of the phenomena, they should have proved the existence of such a fluid, or at least brought forward such circumstances, as rendered its existence credible. But supposing we grant them the hypothesis, it will, in my opinion, not avail much; for it is not easy to conceive how the motion of a subtile fluid, or the vibration of a nerve, can cause sensation.

Nor are the internal senses, as they are generally called, namely, memory, and imagination, any better explained on this supposition; for we cannot conceive how this nervous fluid is stored up and propelled by the will.

After all, I think we must confess, that this subject is still enveloped in obscurity. One observation is worth making, namely, that our sensations have not the smallest resemblance to the substance or impression, which causes them; thus the sensation occasioned by the smell of camphor, possesses not the smallest resemblance to small particles of camphor floating in the atmosphere; a sensation of pain has no similitude whatever to the point of a sword which occasions it; nor has the sensation of sound any resemblance to waves or tremors in the air. In our present state of knowledge, therefore, all that we can say, is, that nature has so formed us, that when an impression is made on any of the organs of sense, it causes a sensation, which forces us to believe in the existence of an external object, though we cannot see any connexion between the sensation and the object which produces it.

But though philosophers were certainly blameable for assuming an unknown cause, to account for various phenomena, yet later experiments would seem to prove that even the conjectures of Newton were not founded on slight grounds. His idea that the diamond was inflammable, has been confirmed by various experiments: and that there exists in nature a subtile fluid, capable of pervading with ease the densest bodies, the phenomena of electricity would seem to show, and some late experiments render it by no means improbable, that this fluid or influence, acts a conspicuous part in the nervous system. That it exists in great quantity in animal bodies, is evident on gently rubbing the back of a cat in the dark; and it would seem that, in some instances, it may be given out or secreted by the nerves. We shall afterwards see that the seat of vision is a delicate expansion of a large nerve which comes from the brain, and is spread out on the bottom of the eye; and flashes of light, or a kind of sparkling, is often seen to dart from the eyes of persons in high health, and possessed of much nervous energy. These luminous flashes are very apparent in the dark in some animals; such as the lion, the lynx, and the cat; and it is difficult to account for this appearance unless we suppose it electrical.

The experiments of Galvani and others, have however proved beyond all doubt, that this fluid, when applied to the nerves and muscles, is capable of exciting various sensations and motions. To produce this fluid by the application of two metals, it is necessary that one of them should be in such a situation, as to be easily oxidable, while the other is prevented from oxidation. If a piece of zinc be put into water, no change will take place; but if a piece of silver be put along with it, the zinc will immediately oxidate, by decomposing the water, and a current of electricity will pass through the silver. If the upper and under surfaces of the tongue be coated with two different metals, one of which is easily oxidable, and these be brought into contact, a sensation is produced resembling taste, which takes place suddenly, like a slight electrical shock. This taste may likewise be produced by applying one part of the metals to the tongue and the other to any part of the body deprived of the cuticle, and bringing them in contact.

The sensation of light may be produced in various ways; such as by applying one metal between the gum and the upper lip, and the other under the tongue; or by putting a silver probe up one of the nostrils, and a piece of zinc upon the tongue; a sensation resembling a very strong flash of light is perceived in the corresponding eye, at the instant of contact.

But the experiments which tend most strongly to prove what I have hinted, are made in the following manner. Lay bare a portion of a great nerve leading to any muscle or limb of an animal, for instance, the leg of a frog separated from the body. Touch the bared nerve with a piece of zinc, and the muscle with a piece of silver, and strong contractions take place the instant these metals are brought into contact. The same effect may be produced by placing a piece of silver on a larger piece of zinc, and putting a worm or a leech on the silver; in moving about, the instant it touches the zinc it is thrown into strong convulsions.

These phenomena have been clearly proved to be electrical; for by a number of pieces of these metals, properly disposed, strong shocks can be given, the electrometer can be affected, a Leyden vial charged, the electric spark seen, and combustible bodies inflamed.

Some animals likewise possess the power of accumulating this influence in a great degree; for instanc the torpedo, and electrical eel, which will both give strong shocks; and if the circuit have a small interruption a spark may be seen, as was shown by Mr. Walsh. On dissecting these fish, Mr. Hunter found an organ very similar to the pile of Volta; it consists of numerous membranaceous columns, filled with plates or pellicles, in the form of thin disks, separated from each other by small intervals, which intervals contain a fluid substance; this organ, like the pile of Volta, is capable of giving repeated shocks, even when surrounded by water.

It is not absolutely necessary to use two metals to produce the galvanic phenomena; for if one side of a metal be made to oxidate, while the other is prevented from oxidation, these appearances will still be produced. It is not indeed necessary to use any metal; for a piece of charcoal, oxidated in the same way, produces galvanism; so does fresh muscular fibre, and perhaps any substance capable of oxidation. The most striking circumstance in galvanism, is, that it accompanies oxidation, and is perhaps never produced without it. But oxidation is always going on in the body by means of respiration and the circulation of the blood. We shall afterwards find reason to believe, that the oxygen, received from the atmosphere by the lungs, is the cause of animal heat, and probably of animal irritability; and it is perhaps not unreasonable to suppose, that the nervous influence or electricity may be separated by the brain, and sent along the nerves, which seem the most powerful conductors of it, to stimulate the muscles to action.