Kitabı oku: «Darwin’s Children»

CHAPTER TWO Center for Ancient Viral Studies, United States Army Medical Research Institute of Infectious Diseases: USAMRIID FORT DETRICK, MARYLAND

“People died, Christopher,” Marian Freedman said. “Isn’t that enough to make us cautious, even a little crazy?”

Christopher Dicken walked beside her, tilting on his game leg, staring down the concrete corridor to the steel door at the end. His National Cancer Institute ID badge still poked from his jacket pocket. He clutched a large bouquet of roses and lilies. The two had been engaged in debate from the front desk through four security checkpoints.

“Nobody’s diagnosed a case of Shiver for a decade,” he said. “And nobody ever got sick from the children. Isolating them is politics, not biology.”

Marian took his day pass and ran it through the scanner. The steel door opened to a horizontal spread of sunglass-green access tubes, suspended like a hamster maze over a two-acre basin of raw gray concrete. She held out her hand, letting him go first. “You know about Shiver firsthand.”

“It went away in a couple of weeks,” Dicken said.

“It lasted five weeks, and it damned near killed you. Don’t bullshit me with your virus hunter bravado.”

Dicken stepped slowly onto the catwalk, having difficulty judging depth with just one eye, and that covered by a thick lens. “The man beat his wife, Marian. She was sick with a tough pregnancy. Stress and pain.”

“Right,” Marian said. “Well, that certainly wasn’t true with Mrs. Rhine, was it?”

“Different problem,” Dicken admitted.

Freedman smiled with little humor. She sometimes revealed biting wit, but did not seem to understand the concept of humor. Duty, hard work, discovery, and dignity filled the tight circle of her life. Marian Freedman was a devout feminist and had never married, and she was one of the best and most dedicated scientists Dicken had ever met.

Together, they marched north on the aluminum catwalk. She adjusted her pace to match his. Tall steel cylinders waited at the ends of the access tubes, shaft housings for elevators to the chambers beneath the seamless concrete slab. The cylinders wore big square “hats,” high-temperature gas-fired ovens that would sterilize any air escaping from the facilities below.

“Welcome to the house that Augustine built. How is Mark, anyway?”

“Not happy, last time I saw him,” Dicken said.

“Why am I not surprised? Of course, I should be charitable. Mark moved me up from studying chimps to studying Mrs. Rhine.”

Twelve years before, Freedman had headed a primate lab in Baltimore, during the early days when the Centers for Disease Control had launched the task force investigating Herod’s plague. Mark Augustine, then director of the CDC and Dicken’s boss, had hoped to secure extra funding from Congress during a fiscal dry spell. Herod’s, thought to have caused thousands of hideously malformed miscarriages, had seemed like a terrific goad.

Herod’s had quickly been traced to the transfer of one of thousands of Human Endogenous Retroviruses—HERV—carried by all people within their DNA. The ancient virus, newly liberated, mutated and infectious, had been promptly renamed SHEVA, for Scattered Human Endogenous Viral Activation.

In those days, viruses had been assumed to be nothing more than selfish agents of disease.

“She’s been looking forward to seeing you,” Freedman said. “How long since your last visit?”

“Six months,” Dicken said.

“My favorite pilgrim, paying his respects to our viral Lourdes,” Freedman said. “Well, she’s a wonder, all right. And something of a saint, poor dear.”

Freedman and Dicken passed junctions with tubes branching southwest, northeast, and northwest to other shafts. Outside, the summer morning was warming rapidly. The sun hung just above the horizon, a subdued greenish ball. Cool air pulsed around them with a breathy moan.

They came to the end of the main tube. An engraved Formica placard to the right of the elevator door read, “MRS. CARLA RHINE.” Freedman punched the single white button. Dicken’s ears popped as the door closed behind them.

SHEVA had turned out to be much more than a disease. Shed only by males in committed relationships, the activated retrovirus served as a genetic messenger, ferrying complicated instructions for a new kind of birth. SHEVA infected recently fertilized human eggs—in a sense, hijacked them. The Herod’s miscarriages were first-stage embryos, called “interim daughters,” not much more than specialized ovaries devoted to producing a new set of precisely mutated zygotes.

Without additional sexual activity, the second-stage zygotes implanted and covered themselves with a thin, protective membrane. They survived the abortion of the first embryo and started a new pregnancy.

To some, this had looked like a kind of virgin birth.

Most of the second-stage embryos had gone to term. Worldwide, in two waves separated by four years, three million new children had been born. More than two and a half million of the infants had survived. There was still controversy over exactly who and what they were—a diseased mutation, a subspecies, or a completely new species.

Most simply called them virus children.

“Carla’s still cranking them out,” Freedman said as the elevator reached the bottom. “She’s shed seven hundred new viruses in the last four months. About a third are infectious, negative-strand RNA viruses, potentially real bastards. Fifty-two of them kill pigs within hours. Ninety-one are almost certainly lethal to humans. Another ten can probably kill both pigs and humans.” Freedman glanced over her shoulder to see his reaction.

“I know,” Dicken said dryly. He rubbed his hip. His leg bothered him when he stood for more than fifteen minutes. The same White House explosion that had taken his eye, twelve years ago, had left him partially disabled. Three rounds of surgery had allowed him to put aside the crutches but not the pain.

“Still in the loop, even at NCI?” Freedman asked.

“Trying to be,” he said.

“Thank God there are only four like her.”

“She’s our fault,” he said, and paused to reach down and massage his calf.

“Maybe, but Mother Nature’s still a bitch,” Freedman said, watching him with her hands on her hips.

A small airlock at the end of the concrete corridor cycled them through to the main floor. They were now fifty feet below ground. A guard in a crisp green uniform inspected their passes and permission papers and compared them with the duty and guest roster at her workstation.

“Please identify,” she told them. Both placed their eyes in front of scanners and simultaneously pressed their thumbs onto sensitive plates. A female orderly in hospital greens escorted them to the cleanup area.

Mrs. Rhine was housed in one of ten underground residences, four of them currently occupied. The residences formed the center of the most redundantly secure research facility on Earth. Though Dicken and Freedman would never come any closer than seeing her through a four-inch-thick acrylic window, they would have to go through a whole-body scrub before and after the interview. Before entering the viewing area and staging lab, called the inner station, they would put on special hooded undergarments impregnated with slow-release antivirals, zip up in plastic isolation suits, and attach themselves to positive pressure umbilical hoses.

Mrs. Rhine and her companions at the center never saw real human beings unless they were dressed to resemble Macy’s parade balloons.

On leaving, they would stand under a disinfectant shower, then strip down and shower again, scrubbing every orifice. The suits would be soaked and sterilized overnight, and the undergarments would be incinerated.

The four women interned at the facility ate well and exercised regularly. Their quarters—each roughly the size of a two-bedroom apartment—were maintained by automated servants. They had their hobbies—Mrs. Rhine was a great one for hobbies—and access to a wide selection of books, magazines, TV shows, and movies.

Of course, the women were becoming more and more eccentric.

“Any tumors?” Dicken asked.

“Official question?” Freedman asked.

“Personal,” Dicken said.

“No,” Freedman said. “But it’s only a matter of time.”

Dicken handed the flowers to the orderly. “Don’t boil them,” he said.

“I’ll process them myself,” the orderly promised with a smile. “She’ll get them before you’re done here.” She passed them two sealed white paper bags containing their undergarments and showed them the way to the scrub stalls, then to the tall cabinets that held the isolation suits, as glossy and green as dill pickles.

Christopher Dicken was legendary even at Fort Detrick. He had tracked Mrs. Rhine to a motel in Bend, Oregon, where she had fled after the death of her husband and daughter. He had talked her into opening the door to the small, spare room, and had spent twenty minutes with her, unprotected, while Emergency Action vans gathered in the parking lot.

He had done all this, despite having already contracted Shiver from a woman in Mexico the year before. That woman, a plump female in her forties, seven months pregnant, had been severely beaten by her husband. A small, stupid, jackal-like man with a long criminal record, he had kept her alone and without medical help in a small room at the back of a shabby apartment for three months. Her baby had been born dead.

Something in the woman had produced a defensive viral response, enhanced by SHEVA, and her husband had suffered the consequences. In his darkest early morning vigils of pacing, tending phantom twitches and pains in his leg, alone and wide awake, Dicken had often thought of the husband’s death as natural justice, and his own exposure and subsequent illness as accidental blow-by—an occupational hazard.

Mrs. Rhine’s case was different. Her problems had been caused by an interplay of human and natural forces no one could have possibly predicted.

In the late nineties, she had suffered from end-stage renal disease and had been the recipient of an experimental xenotransplant—a pig kidney. The transplant had worked. Three years later, Mrs. Rhine had contracted SHEVA from her husband. This had stimulated an enthusiastic release of PERV—Porcine Endogenous Retrovirus—from the pig cells. Before Mrs. Rhine had been diagnosed and isolated at Fort Detrick, her pig and human retroviruses had shuffled genes—recombined—with latent herpes simplex virus and had begun to express, with diabolical creativity, a Pandora’s box of long-dormant diseases, and many new ones.

Ancient viral tool kits, Mark Augustine had called them, with true prescience.

Mrs. Rhine’s husband, newborn daughter, and seven relatives and friends had been infected by the first of her recombined viruses. They had all died within hours.

Of forty-one individuals who had received pig tissue transplants in the United States, and had subsequently been exposed to SHEVA, the women at the center were the only survivors. Perversely, they were immune to the viruses they produced. Isolated as they were, the four women never caught colds or flu. That made them extraordinary subjects for research—deadly but invaluable.

Mrs. Rhine was a virus hunter’s dream, and whenever Dicken did dream about her, he awoke in a cold sweat.

He had never told anyone that his approach to Mrs. Rhine in that motel room in Bend had had less to do with courage than with a reckless indifference. Back then, he simply had not cared whether he lived or died. His entire world had been turned upside down, and everything he thought he knew had been subjected to a harsh and unmerciful glare.

Mrs. Rhine was special to him because they had both been through hell.

“Suit up,” Freedman said. They took off their clothes in separate stalls and hung them in lockers. Small video screens mounted beside the multiple shower heads in each stall reminded them where and how to scrub.

Freedman helped Dicken pull his undergarment over his stiff leg. Together, they tugged on thick plastic gloves, then slipped their hands into the mitts of the pickle-green suits. This left them with all the manual dexterity of fur seals. Fingerless suits were tougher, more secure, and cheaper, and nobody expected visitors to the inner station to do delicate lab work. Small plastic hooks on the thumb side of each glove allowed them to pull up the other’s rear zipper, then strip away a plastic cover on the inner side of a sticky seam. A special pinching tool pressed the seam over the zipper.

This took twenty minutes.

They walked through a second set of showers, then through another airlock. Confined within the almost airless hood, Dicken felt perspiration bead his face and slide down his underarms. Beyond the second airlock, each hooked the other to their umbilicals—the familiar plastic hoses suspended on clanking steel hooks from an overhead track.

Their suits plumped with pressure. The flow of fresh cool air revived him.

The last time, at the end of his visit, Dicken had emerged from his suit with a nosebleed. Freedman had saved him from weeks of quarantine by diagnosing and stanching the bleeding herself.

“You’re good for the inner,” the orderly told them through a bulkhead speaker.

The last hatch slid open with a silky whisper. Dicken walked ahead of Freedman into the inner station. In sync, they turned to the right and waited for the steel window blinds to ratchet up.

The few incidents of Shiver had started at least a hundred crash courses in medical and weapons-related research. If abused women, and women given xenotransplants, could all by themselves design and express thousands of killer plagues, what could a generation of virus children do?

Dicken clenched his jaw, wondering how much Carla Rhine had changed in six months.

Something of a saint, poor dear.