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Synthetic Methods for Biologically Active Molecules
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Synthetic Methods for Biologically Active Molecules

Exploring the Potential of Bioreductions
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This useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. <br> <br> Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio-reductions for the synthesis of active pharmaceutical ingredients. <br> <br> With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry.<br> <br> <br> From the contents:<br> * Development of Sustainable Biocatalyzed Reduction Processes for Organic Chemists<br> * Reductases: From Natural Diversity to Biocatalysis and Emerging Enzymatic Activities.<br> * Synthetic Strategies Based on C=C Bioreductions<br> * Synthetic Strategies Based on C=O Bioreductions<br> * Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds<br> * Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds<br> * Synthetic Applications of Aminotransferases<br> * Strategies for Cofactor Regeneration in Biocatalyzed Reductions<br> * Effects of Solvent System and Substrate Loading in Bioreduction<br> * Perspectives in the Use of In-Situ Product Removal (ISPR) Techniques in Bioreductions<br> * Multi-Enzymatic Cascade Reactions Based on Reduction Processes<br> * Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients<br>

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Yaş sınırı:
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Litres'teki yayın tarihi:
24 temmuz 2018
Hacim:
407 s.
ISBN:
9783527665815
Toplam boyut:
14 МБ
Toplam sayfa sayısı:
407
Yayıncı: